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KMID : 0043320010240020109
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Archives of Pharmacal Research
2001 Volume.24 No. 2 p.109 ~ p.113
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Anticoagulant Activity of Sulfoalkyl Derivatives of Curdan
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Lee KB
Bae JH/Kim Js/Yoo YC/Kim BS/Kwak ST/Kim YS
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Abstract
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Curdlan is a natural beta-1, 3-glucan produced by Agrobacterium biovar 1. In this study, the anticoagulant activity of sulfoalkyl deribatives of curdlan was investigted by carry ing out activated partial thromboplastin time(APTT) assay and compared with that of o-sulfonated curdlan. Approximately 100-fold higher concentration of o-sulfonated curdlan than heparin was required to obtain the same level of the clotting time. Anticoagulant activity of curdlan deribatives was dependent on the degree of sulfation in prolonging the clotting time. However, the chain length of the substituent did not play a role in prolonging the clotting time. The curdlan derivatives enhanced thrombin inhibition curdlan was found to be approximately 10-fold weaker than that by heparin.
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